William W Hauswirth Selected Research

Blindness (Hysterical Blindness)

1/2020	Long-Term Structural Outcomes of Late-Stage RPE65 Gene Therapy.
1/2018	Overexpression of Type 3 Iodothyronine Deiodinase Reduces Cone Death in the Leber Congenital Amaurosis Model Mice.
1/2016	PAX6 MiniPromoters drive restricted expression from rAAV in the adult mouse retina.
10/2015	Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice.
5/2015	Improvement and decline in vision with gene therapy in childhood blindness.
11/2014	DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration.
6/2013	Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1.
2/2013	Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement.
8/2012	ERK1/2 activation is a therapeutic target in age-related macular degeneration.
5/2012	DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

William W Hauswirth Research Topics

Disease

26	Retinal Degeneration 01/2020 - 01/2003
22	Retinitis Pigmentosa (Pigmentary Retinopathy) 10/2021 - 01/2004
18	Blindness (Hysterical Blindness) 01/2020 - 11/2005
13	Color Vision Defects (Color Blindness) 10/2021 - 06/2008
12	Leber Congenital Amaurosis 01/2020 - 03/2006
11	Leber Hereditary Optic Atrophy (Leber's Hereditary Optic Neuropathy) 01/2022 - 02/2003
10	Macular Degeneration (Age-Related Maculopathy) 11/2015 - 06/2002
9	Glaucoma 01/2022 - 06/2002
9	Ganglion Cysts (Ganglion) 01/2020 - 03/2003
6	Choroidal Neovascularization 10/2019 - 06/2002
6	Optic Nerve Diseases (Optic Neuropathy) 10/2016 - 02/2003
5	Blue cone monochromatism 10/2021 - 01/2017
5	Inflammation (Inflammations) 05/2015 - 05/2005
5	Retinal Diseases 01/2013 - 01/2004
4	Photophobia (Light Sensitivity) 12/2017 - 10/2009
4	Retinal Detachment (Retinal Detachments) 01/2017 - 03/2009
4	Ischemia 01/2017 - 06/2002
4	Retinal Neovascularization 01/2016 - 06/2002
4	Geographic Atrophy 11/2014 - 03/2011
4	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 07/2014 - 10/2006
3	Disease Progression 01/2020 - 06/2008
3	Uveitis 02/2016 - 01/2015
3	Blister (Bulla) 01/2016 - 10/2012
3	Retinal Dystrophies 02/2015 - 02/2008
3	Usher Syndromes (Usher Syndrome) 04/2014 - 07/2009
3	Multiple Sclerosis 10/2013 - 01/2007
3	Mitochondrial Diseases (Mitochondrial Disease) 10/2013 - 02/2003
3	Demyelinating Diseases (Demyelinating Disease) 12/2007 - 02/2003
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 06/2013
2	Optic Nerve Injuries 01/2020 - 03/2013
2	Vision Disorders (Hemeralopia) 12/2018 - 05/2008
2	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2018 - 01/2012
2	Hemorrhage 01/2016 - 10/2012
2	Cone-Rod Dystrophies 02/2015 - 01/2013
2	Optic Atrophy 07/2014 - 01/2012
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2014 - 05/2008
2	Channelopathies 06/2013 - 07/2010
2	Infections 02/2012 - 04/2011
2	Fibrosis (Cirrhosis) 01/2009 - 12/2005
2	Chronic Renal Insufficiency 01/2009 - 12/2005
2	Proteinuria 01/2009 - 12/2005
2	Optic Neuritis (Retrobulbar Neuritis) 12/2007 - 01/2007
1	Ocular Hypertension (Glaucoma, Suspect) 01/2022

Drug/Important Bio-Agent (IBA)

49	Retinaldehyde (Retinal)IBA 11/2019 - 06/2002
13	Proteins (Proteins, Gene)FDA Link 05/2015 - 10/2006
10	Rhodopsin (Visual Purple)IBA 10/2021 - 08/2005
7	Catalytic RNA (Ribozymes)IBA 10/2005 - 02/2003
6	Mitochondrial DNA (mtDNA)IBA 01/2022 - 02/2007
6	OpsinsIBA 01/2019 - 01/2004
5	Cone OpsinsIBA 10/2021 - 02/2008
5	RNA (Ribonucleic Acid)IBA 11/2014 - 10/2005
5	Messenger RNA (mRNA)IBA 11/2011 - 02/2003
4	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2017 - 10/2005
4	RetinoidsIBA 05/2015 - 06/2007
4	Green Fluorescent ProteinsIBA 01/2015 - 10/2003
4	Ciliary Neurotrophic Factor (CNTF)IBA 05/2009 - 09/2003
4	AntioxidantsIBA 12/2007 - 01/2007
3	pigment epithelium-derived factorIBA 01/2020 - 06/2002
3	Complementary DNA (cDNA)IBA 01/2019 - 09/2008
3	GTP Phosphohydrolases (GTPases)IBA 12/2018 - 02/2012
3	N- (4- azidobenzoylglycyl)- S- (2- thiopyridyl)cysteine (AGTC)IBA 12/2018 - 03/2016
3	Oxygen (Dioxygen)IBA 01/2017 - 11/2005
3	EndotoxinsIBA 02/2016 - 01/2015
3	c-Mer Tyrosine KinaseIBA 01/2016 - 04/2012
3	EnzymesIBA 11/2014 - 09/2006
3	Tyrosine (L-Tyrosine)FDA Link 03/2014 - 02/2011
2	Electron Transport Complex I (NADH-CoQ Reductase)IBA 01/2022 - 01/2012
2	NAD (NADH)IBA 01/2020 - 04/2014
2	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 04/2014
2	Complement System Proteins (Complement)IBA 10/2018 - 10/2003
2	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 04/2009
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2016 - 11/2005
2	Hyaluronic Acid (Hyaluronan)IBA 01/2016 - 03/2009
2	InflammasomesIBA 11/2014 - 05/2012
2	WD repeat containing planar cell polarity effectorIBA 01/2014 - 04/2012
2	Guanylate Cyclase (Guanylyl Cyclase)IBA 10/2013 - 02/2013
2	Cyclic NucleotidesIBA 06/2013 - 01/2012
2	Small Interfering RNA (siRNA)IBA 05/2013 - 08/2012
2	Pharmaceutical PreparationsIBA 03/2013 - 06/2002
2	NADH dehydrogenase subunit 4IBA 01/2013 - 01/2012
2	Superoxides (Superoxide)IBA 02/2012 - 01/2007
2	MicroRNAs (MicroRNA)IBA 03/2011 - 05/2008
2	TransducinIBA 01/2010 - 10/2009
2	Neuroprotective AgentsIBA 05/2009 - 12/2007
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 05/2009 - 10/2003
2	Nerve Growth Factors (Neurotrophins)IBA 05/2009 - 01/2004
2	AngiostatinsIBA 01/2009 - 06/2002
2	CreatinineIBA 01/2009 - 12/2005
2	CatalaseIBA 12/2007 - 01/2007
2	Superoxide DismutaseIBA 01/2007 - 03/2003
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2007 - 03/2003
2	Interleukin-10 (Interleukin 10)IBA 12/2005 - 05/2005
1	DNA (Deoxyribonucleic Acid)IBA 01/2022

Therapy/Procedure

40	Therapeutics 01/2022 - 10/2003
7	Intravitreal Injections 02/2016 - 10/2003
6	Lasers (Laser) 10/2019 - 10/2003
3	Intraocular Injections 10/2015 - 06/2002
2	Injections 10/2012 - 08/2006
2	Nephrectomy 01/2009 - 12/2005
1	Microspheres (Microsphere) 01/2022